The workshop will be a fully in-person meeting, [b]held on 27-29 June 2022 at the Hotel Zuiderduin in Egmond aan Zee, The Netherlands[/b]. Please visit www.europdxworkshop.eu to know everything about the scientific programme and how to register and submit an abstract. As the first two workshops, we ...
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The last EurOPDX Workshop in 2018 feels like ages ago. After two years of COVID-19 pandemic and having postponed the 3 rd edition several times, we are delighted to announce that the next EurOPDX Workshop will be held on 27-29 June 2022 at the Hotel Zuiderduin in Egmond aan Zee, The Netherlands. The...
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CONSERVATION OF COPY NUMBER PROFILES DURING ENGRAFTMENT AND PASSAGING OF PATIENT-DERIVED CANCER XENOGRAFTS Cancer is one of the major causes of death in Europe. Therefore identification, validation and optimisation of therapeutic strategies to improve survival and quality of life of cancer patients ...
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After internal consultation, Prof. Enzo Medico, the Coordinator of the EurOPDX Distributed Infrastructure for Research of patient-derived Xenografts (EDIReX), appointed Dr. Massimiliano Borsani as Research Infrastructure Manager of the project. Massimiliano is the first to hold this new position an...
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Summary: The NORLUX Neuro-Oncology Laboratory at the Luxembourg Institute of Health (LIH) Department of Oncology, in collaboration with multiple local and international partners, established a large collection of patient-derived glioma organoids and xenograft models that mimic the specific feature...
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We just released a few days ago a new v2.0 version of our repository, the EurOPDX Data Portal. The Portal now displays a total of 995 PDX models with associated metadata and, for many of them, cytogenetics, gene mutation, expression data, copy number alterations, and drug efficacy data. Of these mod...
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As part of the EU-funded EDIReX project, we just launched our 3rd and last call for free-of-charge access to the PDX models, resources and expertise of the EurOPDX Research Infrastructure, in the form of an OPEN CALL. The three types of access SAMPLE, DEPOSIT and TEST are available, and hands-on tra...
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The manager of the EurOPDX Research Infrastructure, Emilie Vinolo (seeding science SRL, Limelette, Belgium), will attend the 41st EORTC-PAMM meeting held in Stockholm on 13th-15th February 2020. She will give a short talk in the afternoon session on Friday 14th February in order to present the EurOP...
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The 1st call for Trans-national Access (TA) of the EurOPDX Research Infrastructure closed at the beginning of the year. Successful candidates were notified of acceptance of their projects at the end of March 2019, and we are pleased to announce that these projects are now underway, covering a divers...
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Between the 19th and 21st of June 2019, the Netherlands Cancer Institute (NKI) and the Leiden University Medical Center (LUMC) organise the 10th edition of the workshop on Innovative Mouse Models (IMM2019) in Leiden, the Netherlands. The goal of IMM2019 is to bring together a diverse group of scien...
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Both the EurOPDX Research Infrastructure and EurOPDX consortium were present at the American Association of Cancer Research (AACR) annual meeting in Atlanta, Georgia, from the 29th March to the 3rd April 2019. The AACR Annual meeting is a renowned forum, covering a full spectrum of cancer research ...
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Are you a Bioinformatician or data scientist who wants to integrate & mine genomic/phenotypic cancer data? Do you have the skills to research, design, & develop analyses for data of genetic contributors to cancer? If so, then PDX Finder and EMBL-EBI are looking for you! ...
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The microbiological status of PDX models directly influences both experimental variability and animal welfare. It also imposes a risk to the personnel involved in experimentation. In order to guarantee biosecurity, ensure the quality of the PDX samples, and facilitate the transfer of samples between...
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The IABCR 2019 (31st Conference of the International Association for Breast Cancer Research) will be held on April 15-18, 2019 at Hotel Zuiderduin, Egmond aan Zee, The Netherlands. IABCR Conferences are international biannual meetings focusing on the molecular mechanisms underlying breast cancer de...
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76 Gastric PDX models from the University of Torino, Candiolo Cancer Institute, have now been added to our EurOPDX Data Portal. Our collection now totals 720 PDX models for 3 cancer types. We are continually adding new models, so check back regularly. The EurOPDX Research Infrastructure 1st call f...
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++ UPDATED SAMPLE APPLICATION FORM ++ Now you can apply for access to GASTRIC and BREAST PDX models that are not yet visible on the EurOPDX Data Portal In the updated "Part 3" of the application form, you can now list your desired model(s) by: /cancer type /sub-type /particular molecu...
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We are offering free-of-charge access to the PDX models, resources, and expertise of the EurOPDX Research Infrastructure (EurOPDX RI), as part of the EU-funded EDIReX project. Known as Trans-national Access (TA) grants, we welcome proposals in two forms: 1) SAMPLE – where researchers can request...
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The IABCR 2019 (31st Conference of the International Association for Breast Cancer Research) will be held on April 15-18, 2019 at Hotel Zuiderduin, Egmond aan Zee, The Netherlands. IABCR Conferences are international biannual meetings focusing on the molecular mechanisms underlying breast cancer de...
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As part of the EU-funded EDIReX project, we are offering free-of-charge access to the PDX models, resources, and expertise of the EurOPDX Research Infrastructure (RI). Known as Trans-national Access (TA) grants, we welcome proposals in two forms:, 1) SAMPLE – where researchers can request PDX mod...
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The CORBEL1 Open Call invites researchers from academia and industry to apply for access to a wide range of high-end technologies and services from more than 20 facilities across 10 different research infrastructures within Europe. These include state-of-the-art offerings from the fields of advance...
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EurOPDX Consortium partners at the Vall d’Hebron Institute of Oncology (VHIO) in Barcelona, Spain, in collaboration with the Roche Innovation Center Zurich and other academic institutions, have developed a novel T-cell bispecific antibody with a potent anti-tumour effect for breast cancer treatmen...
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The 2018 EurOPDX workshop is nearly upon us. We excited to welcome attendees from 19 countries, and are pleased to announce that we have a full house this year! All you need to know about this 2nd edition of the EurOPDX workshop can be found on the event website: www.europdxworkshop.eu In addition...
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TRACE, a multidisciplinary project focused on the development of Patient-Derived Xenograft (PDX) models, is set up within the department of Oncology at the KU Leuven and it is part of the Leuvens Kankerinstitute (LKI, uzleuven-kuleuven.be). The platform was created in 2012 aiming to narrow the gap b...
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Registration for the second edition of the EurOPDX Workshop has now closed. We are happy to announce that we will have a full house in October. We look forward to welcoming all attendees to beautiful Weggis, Switzerland for what promises to be a fascinating meeting. To see our invited speaker li...
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The team of Prof. Silvia Giordano and Dr. Simona Corso at the Department of Oncology, University of Torino/Candiolo Cancer Institute, FPO-IRCCS (Candiolo, Italy) have, over the past few years, established a unique collection of gastric carcinoma PDX models. Gastric tumour samples and matched normal...
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EDIReX, a four-year project funded as part of the EU Horizon2020 Research and Innovation Program (grant agreement no #731105), kicked-off earlier this year and was introduced by project coordinator Prof. Enzo Medico at the 2018 AACR annual meeting in Chicago. EDIReX stands for “EurOPDX Distribute...
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You may be wondering what we have been working at the past few months, as we have been quite silent at least on the website. Well, if you have the chance to attend the AACR meeting this year (April 14-18 in Chicago, Illinois USA), you will get a chance to know more about it. Prof. Enzo Medico (Univ...
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EurOPDX members RCSI, UNITO and VHIO are key partners in a new international research study “COLOSSUS”, which aims to provide novel and more effective ways to classify and treat patients with a specific type of colorectal cancer (MSS RAS mt CRC). The team has secured approximately €6 million ...
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We are delighted to announce that the second edition of the EurOPDX Workshop will be held on October 1-3, 2018 at the same venue in Weggis, Switzerland. Although we are keeping a similar size (100-120 attendees), the format may evolve from the first edition to take into account the feedback received...
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Glioblastoma (GBM), an aggressive and devastating form of brain tumour, will be the focus of the new four-year project GLIOTRAIN just awarded a 3.9 million euros grant from the European Commission’s Horizon 2020 Marie Sklodowska-Curie Innovative Training Network (ITN) initiative. The project, co-o...
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Trace (http://www.uzleuven-kuleuven.be/lki/trace), a multidisciplinary project focused on patient-derived xenograft (PDX) models at the KU Leuven, is set up within the department of oncology to narrow the gap between preclinical and clinical research by developing a more reliable and predictive in v...
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We presented a poster at the scientific conference organised by the European Commission in Brussels on December 6-7, 2016 to engage the scientific community and relevant stakeholders in a debate on how to exploit cutting edge advances in biomedical and other research in the development of scientific...
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Our first workshop taking place in Weggis, Switzerland on October 3-5 was also an opportunity to present a poster with an update on the current members of the Consortium, our objectives, achievements so far and future directions. You can upload this poster using the following link: https://www.drop...
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Alejandra Bruna and colleagues, from Prof. Carlos Caldas laboratory at the Cancer Research UK Cambridge Institute (CI), recently published in Cell a new experimental platform using patient-derived tumour xenografts (PDTXs) of breast cancer (BC) in high-content preclinical drug screening. This work r...
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It's your lucky day: we have decided to postpone the abstract submission deadline until July 14! You will find all necessary information on the Workshop “PDX models in clinical oncology and cancer precision medicine" on the dedicated webpage: http://www.europdxworkshop2016.eu/ Registration w...
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Registration is now open for our Workshop “PDX models in clinical oncology and cancer precision medicine”, taking place in Weggis, Stwitzerland on October 3-5, 2016. You will find all necessary information on the workshop webpage: http://www.europdxworkshop2016.eu/ For any question you might ...
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The EurOPDX Consortium is now reaching out to the US, with the Board of Coordinators having very recently voted for Weill Cornell Medical College (WCM) in New York (NY, USA) to join. Our collaboration with WCM started a few months ago for the set-up of an instance of the cBioPortal dedicated to PDX...
Read moreWe are very excited to announce the organisation of a workshop on "PDX models to interrogate open issues in clinical oncology and cancer precision medicine", which will take place in Weggis, Switzerland on October 3-5, 2016. This educational workshop will feature speakers from the Consorti...
Read moreOn November 27, 2015 we have been celebrating with a PDX Symposium the 3rd anniversary of the PDX platform in the University Hospitals Leuven and Katholieke Universiteit Leuven. Several researchers from Leuven and other institutions have been presenting their work on the establishment and validation...
Read moreThe upcoming Special Conference of the American Association for Cancer Research "Patient-Derived Cancer Models: Present and Future Applications from Basic Science to the Clinic" (New Orleans, February 11-14, 2016) will be co-chaired by our two members Manuel Hidalgo (CNIO, Madrid, Spain) a...
Read moreHosted by the Katholieke Universiteit in Leuven, Belgium, the EurOPDX community recently gathered in order to celebrate the second anniversary of the consortium creation. In a warm atmosphere, this new meeting was an opportunity to review the many achievements of the network since it was initiated t...
Read moreThe Adrea Bertotii, Livio Trusolino and Enzo Medico group just published a very nice work in Science Translational Medicine (Andrea Bertotii et al. Sci Transl Med 28 January 2015 7:272ra12. DOI:10.1126/scitranslmed.3010445) (http://stm.sciencemag.org/content/7/272/272ra12.abstract?sid=ae24ed4a-9b05-...
Read moreHosted by the Vall d'Hebron Institute of Oncology (VHIO) in Barcelona, Spain, the EurOPDX community met in November 2014 for the 5th time. This meeting was an opportunity to review the progress of the different collaborative projects pursued by the Consortium. But the main objective was to discuss a...
Read moreThe EurOPDX Consortium just published a very comprehensive review in Cancer Discovery (Hidalgo, M. et al. Cancer Discov; 4(9); 998–1013; http://www.ncbi.nlm.nih.gov.gate2.inist.fr/pubmed/?term=25185190). This article summarises the current state of the art in the field of PDX models, including met...
Read moreScientists of the EurOPDX Consortium will be major contributors to the upcoming "Applications of Patient Derived Xenograft Models to Translational Cancer Research". This workshop will indeed be chaired by Dr. Manuel Hidalgo (CNIO, Madrid, Spain) and will feature a presentation by Dr. Andre...
Read moreFor the first time, the project of the EurOPDX Consortium will be presented as a poster at the next AACR-NCI-EORTC meeting in Boston, by its project manager Emilie Vinolo. Come and let us introduce you our project at the poster session!...
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