The Adrea Bertotii, Livio Trusolino and Enzo Medico group just published a very nice work in Science Translational Medicine (Andrea Bertotii et al. Sci Transl Med 28 January 2015 7:272ra12. DOI:10.1126/scitranslmed.3010445) (http://stm.sciencemag.org/content/7/272/272ra12.abstract?sid=ae24ed4a-9b05-409d-af00-dedf7abeec03). This beautiful work through the use of PDX models in the context of colorectal cancer, has identified a new therapeutic target: IGF2. The study conducted on 125 different samples demonstrates with clarity the different mechanisms involved in treatment response and is very promising in the individualized treatment of colorectal cancers.