The PDX Collection
Altogether, the members of the EurOPDX Consortium have established a panel of more than 1,500 subcutaneous and orthotopic PDX models for more than 30 pathologies (see outline for main cancer types below). These models and their phenotypic and molecular traits have been poorly visible outside of publications in scientific journals or presentations at congresses, and are so far only accessible through discrete collaborative projects.
As part of the EurOPDX Research Infrastructure project (Project EDIReX), we have recently launched the EurOPDX Data Portal, a user-friendly and efficient informatics tool to optimize access to-, and data searching of-, our collection of models. Models will be continually added over the coming months.
The EurOPDX Data Portal is built upon the PDX Finder global catalogue search function, and links search queries to cBioPortal and GenomeCruzer for in-depth interrogation of models of interest, and associated molecular data.
A priority in the coming years remains to homogenise the characterisation of models across the collection.
Please contact us with any specific enquiry- Colorectal cancer
- Pancreatic cancer
- Breast cancer
- Lung cancer
- Skin melanoma
- Gynecological cancers
- Head and neck cancer
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Colorectal cancer
- (754)
- 291 primary tumours
- 444 liver mets
- 4 lung mets
- 15 other mets
- Characterisation: 350+ already characterised by transcriptome arrays and targeted sequencing, but also 150+ by WES and 250+ drug monitoring
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Pancreatic cancer
- (235)
- 211 primary tumours
- 24 liver and other mets
- Characterisation: 120+ transcriptomic, 100+ CGH, 120+ WES, 20+ WGS, 70+ RNAseq, 70+ MiR
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Breast cancer
- (161)
- 89 triple negative
- 18 HER2+
- Characterisation: 90+ transcriptomic, 40+ CGH, 40+ WES, drug monitoring
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Lung cancer
- (71)
- 59 NSCLC
- 12 SCLC
- Ongoing characterisation
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Skin melanoma
- (136)
- 3 primary tumours
- 133 subcutaneous and others mets
- Characterisation: 20+ WES, 40+ gene panel, drug monitoring
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Gynecological cancers
- OVARY(142)
- ENDOMETRIAL(77)
- Ongoing characterisation
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Head and neck cancer
- (63)
- 50 primary tumours
- 13 mets
- Ongoing characterisation
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Other Cancers
- Gastric (140)
- Glioma (26, incl. 3 IDH mut)
- Sarcoma (35)
- Renal (27)
- Testicular (18)
- Uveal melanoma (17)
- Paediatric (12)
- Skin squamous cell carcinomas (10)
- ...